General form of almost instantaneous fixed-to-variable-length codes

A general class of the almost instantaneous fixed-to-variable-length (AIFV) codes is proposed, which contains every possible binary code we can make when allowing finite bits of decoding delay. The contribution of the paper lies in the following. (i) Introducing $N$-bit-delay AIFV codes, constructed by multiple code trees with higher flexibility than the conventional AIFV codes. (ii) Proving that the proposed codes can represent any uniquely-encodable and uniquely-decodable variable-to-variable length codes. (iii) Showing how to express codes as multiple code trees with minimum decoding delay. (iv) Formulating the constraints of decodability as the comparison of intervals in the real number line. The theoretical results in this paper are expected to be useful for further study on AIFV codes.Comment: submitted to IEEE Transactions on Information Theory. arXiv admin note: text overlap with arXiv:1607.07247 by other author

Role of RNA-Binding Proteins in MAPK Signal Transduction Pathway

Mitogen-activated protein kinases (MAPKs), which are found in all eukaryotes, are signal transducing enzymes playing a central role in diverse biological processes, such as cell proliferation, sexual differentiation, and apoptosis. The MAPK signaling pathway plays a key role in the regulation of gene expression through the phosphorylation of transcription factors. Recent studies have identified several RNA-binding proteins (RBPs) as regulators of MAPK signaling because these RBPs bind to the mRNAs encoding the components of the MAPK pathway and regulate the stability of their transcripts. Moreover, RBPs also serve as targets of MAPKs because MAPK phosphorylate and regulate the ability of RBPs to bind and stabilize target mRNAs, thus controlling various cellular functions. In this review, we present evidence for the significance of the MAPK signaling in the regulation of RBPs and their target mRNAs, which provides additional information about the regulatory mechanism underlying gene expression. We further present evidence for the clinical importance of the posttranscriptional regulation of mRNA stability and its implications for drug discovery

Switching Head-Tail Funnel UNITER for Dual Referring Expression Comprehension with Fetch-and-Carry Tasks

This paper describes a domestic service robot (DSR) that fetches everyday objects and carries them to specified destinations according to free-form natural language instructions. Given an instruction such as "Move the bottle on the left side of the plate to the empty chair," the DSR is expected to identify the bottle and the chair from multiple candidates in the environment and carry the target object to the destination. Most of the existing multimodal language understanding methods are impractical in terms of computational complexity because they require inferences for all combinations of target object candidates and destination candidates. We propose Switching Head-Tail Funnel UNITER, which solves the task by predicting the target object and the destination individually using a single model. Our method is validated on a newly-built dataset consisting of object manipulation instructions and semi photo-realistic images captured in a standard Embodied AI simulator. The results show that our method outperforms the baseline method in terms of language comprehension accuracy. Furthermore, we conduct physical experiments in which a DSR delivers standardized everyday objects in a standardized domestic environment as requested by instructions with referring expressions. The experimental results show that the object grasping and placing actions are achieved with success rates of more than 90%.Comment: Accepted for presentation at IROS202

DialMAT: Dialogue-Enabled Transformer with Moment-Based Adversarial Training

This paper focuses on the DialFRED task, which is the task of embodied instruction following in a setting where an agent can actively ask questions about the task. To address this task, we propose DialMAT. DialMAT introduces Moment-based Adversarial Training, which incorporates adversarial perturbations into the latent space of language, image, and action. Additionally, it introduces a crossmodal parallel feature extraction mechanism that applies foundation models to both language and image. We evaluated our model using a dataset constructed from the DialFRED dataset and demonstrated superior performance compared to the baseline method in terms of success rate and path weighted success rate. The model secured the top position in the DialFRED Challenge, which took place at the CVPR 2023 Embodied AI workshop.Comment: Accepted for presentation at Fourth Annual Embodied AI Workshop at CVP

PKN3 is the major regulator of angiogenesis and tumor metastasis in mice

PKN, a conserved family member related to PKC, was the first protein kinase identified as a target of the small GTPase Rho. PKN is involved in various functions including cytoskeletal arrangement and cell adhesion. Furthermore, the enrichment of PKN3 mRNA in some cancer cell lines as well as its requirement in malignant prostate cell growth suggested its involvement in oncogenesis. Despite intensive research efforts, physiological as well as pathological roles of PKN3 in vivo remain elusive. Here, we generated mice with a targeted deletion of PKN3. The PKN3 knockout (KO) mice are viable and develop normally. However, the absence of PKN3 had an impact on angiogenesis as evidenced by marked suppressions of micro-vessel sprouting in ex vivo aortic ring assay and in vivo corneal pocket assay. Furthermore, the PKN3 KO mice exhibited an impaired lung metastasis of melanoma cells when administered from the tail vein. Importantly, PKN3 knock-down by small interfering RNA (siRNA) induced a glycosylation defect of cell-surface glycoproteins, including ICAM-1, integrin β1 and integrin α5 in HUVECs. Our data provide the first in vivo genetic demonstration that PKN3 plays critical roles in angiogenesis and tumor metastasis, and that defective maturation of cell surface glycoproteins might underlie these phenotypes

State of the Art : Elbow Arthroscopy : Review of the Literature and Application for Osteochondritis Dissecans of the Capitellum

Elbow arthroscopy has become a safe and effective treatment option for a number of elbow disorders. The most rewarding and successful indication is the removal of loose bodies. Loose bodies are often a result of osteochondritis dissecans (OCD) of the　capitellum, and arthroscopy in this case is useful for performing debridement, thereby eliminating the need for a more extensive open procedure associated with complications. In this review, we describe our arthroscopic technique for OCD of the capitellum. We usually conduct arthroscopy in the supine position, and use 2.9-mm arthroscopes of 30°and 70°. The 70°arthroscope provides a greater operative field than the 30°arthroscope. Arthroscopic treatment for OCD may require 2 anterior and 2 posterior portals. Loose bodies are commonly found in the radial fossa, coronoid fossa, and in the olecranon fossa. Once the loose bodies are removed, all unstable cartilage of the capitellum lesion is removed to create a stable bed. If any sclerotic changes to the lesion bed are observed, we create microfractures in the lesion bed. The most significant complication in arthroplasty is neurovascular injury. However, we have never experienced this devastating complication, which can be avoided by paying careful attention to detail

State of the Art : Transforaminal Approach for Percutaneous Endoscopic Lumbar Discectomy under Local Anesthesia

Minimally invasive percutaneous endoscopic discectomy (PED) with a transforaminal approach under local anesthesia was started in the late 20th century. As the procedure requires a skin incision of only 8mm, it is the least invasive disc surgery procedure at present, and owing to advances in instruments and optics, the use of this technique has gradually spread. In Japan, Dr. Dezawa from Teikyo University Mizonokuchi Hospital introduced this technique in 2003. Thanks to his efforts, the number of surgeons who can perform PED has increased, although the number of active PED surgeons is still only around 20. The first author (K.S.) started PED in 2010. In this review article, we explain the state-of-the-art PED transforaminal technique for minimally invasive disc surgery and present three successful cases

Role of the RNA-Binding Protein Nrd1 in Stress Granule Formation and Its Implication in the Stress Response in Fission Yeast

We have previously identified the RNA recognition motif (RRM)-type RNA-binding protein Nrd1 as an important regulator of the posttranscriptional expression of myosin in fission yeast. Pmk1 MAPK-dependent phosphorylation negatively regulates the RNA-binding activity of Nrd1. Here, we report the role of Nrd1 in stress-induced RNA granules. Nrd1 can localize to poly(A)-binding protein (Pabp)-positive RNA granules in response to various stress stimuli, including heat shock, arsenite treatment, and oxidative stress. Interestingly, compared with the unphosphorylatable Nrd1, Nrd1DD (phosphorylation-mimic version of Nrd1) translocates more quickly from the cytoplasm to the stress granules in response to various stimuli; this suggests that the phosphorylation of Nrd1 by MAPK enhances its localization to stress-induced cytoplasmic granules. Nrd1 binds to Cpc2 (fission yeast RACK) in a phosphorylation-dependent manner and deletion of Cpc2 affects the formation of Nrd1-positive granules upon arsenite treatment. Moreover, the depletion of Nrd1 leads to a delay in Pabp-positive RNA granule formation, and overexpression of Nrd1 results in an increased size and number of Pabp-positive granules. Interestingly, Nrd1 deletion induced resistance to sustained stresses and enhanced sensitivity to transient stresses. In conclusion, our results indicate that Nrd1 plays a role in stress-induced granule formation, which affects stress resistance in fission yeast